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Article

A G-quadruplex-forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1-MTG8 fusion protein from DNA.

FEBS letters - 1 Nov 2020

Fukunaga Junichi, Nomura Yusuke, Tanaka Yoichiro, Torigoe Hidetaka, Nakamura Yoshikazu, Sakamoto Taiichi, Kozu Tomoko

Abstract excerpt

MTG8 (RUNX1T1) is a fusion partner of AML1 (RUNX1) in the leukemic chromosome translocation t(8;21). The AML1-MTG8 fusion gene encodes a chimeric transcription factor. One of the highly conserved domains of MTG8 is TAFH which possesses homology with human TAF4 [TATA-box binding protein-associated factor]. To obtain specific inhibitors of the AML1-MTG8 fusion protein, we isolated RNA aptamers against the MTG8 TAFH...

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Share to Aptamers, Nucleotide
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G-Quadruplexes

Share to Leukemia

Share to Oncogene Proteins, Fusion

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Share to RUNX1 Translocation Partner 1 Protein

Source

Identifiers

PMID: 32870501
DOI: 10.1002/1873-3468.13914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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