Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RNA aptamer inhibiting human vesicular endothelial growth factor receptor 1 without affecting cytokine binding.

Biochemistry - 2 Apr 2013

Ohuchi Shoji P, Shibuya Masabumi, Nakamura Yoshikazu

Abstract excerpt

Angiogenesis, a process of new blood vessel formation, is crucial not only for many physiological events but also for a number of diseases. The signaling pathways through members of the vesicular endothelial growth factor (VEGF) family play fundamental roles in angiogenesis. In this study, we identified inhibitory RNA aptamers against human Flt-1, a receptor of VEGF. One of the isolates, aptamer #38, showed a 50%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to Base Sequence
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin

Share to Inhibitory Concentration 50

Share to Protein Binding

Share to Vascular Endothelial Growth Factor A

Share to Vascular Endothelial Growth Factor Receptor-1

Source

Identifiers

PMID: 23442158
DOI: 10.1021/bi301669p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RNA aptamer inhibiting human vesicular endothelial growth factor receptor 1 without affecting cytokine binding.PMID 23442158Read ↗

Anti‐VEGF DNA‐based aptamers in cancer therapeutics and diagnosticsSemantic proximity Read ↗

Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer TherapeuticsSemantic proximity Read ↗

The 20th Anniversary of Pegaptanib (MacugenTM), the First Approved Aptamer Medicine: History, Recent Advances and Future Prospects of Aptamers in TherapySemantic proximity Read ↗

Design of a Small Molecule That Stimulates VEGFA Informed from an Expanded Encyclopedia of RNA Fold-Small Molecule InteractionsSemantic proximity Read ↗

Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity.Semantic proximity Read ↗

Nucleic Acid-Based Aptamers: Applications, Development and Clinical TrialsSemantic proximity Read ↗

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.Semantic proximity Read ↗

Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.Semantic proximity Read ↗

Nucleic Acid Aptamers Emerging as Modulators of G-Protein-Coupled Receptors: Challenge to Difficult Cell Surface ProteinsSemantic proximity Read ↗

A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth Factor to Its Kinase Domain ReceptorSemantic proximity Read ↗

[Oligonucleotides with aptameric properties].Semantic proximity Read ↗

Albumin-binding Aptamer Chimeras for Improved siRNA BioavailabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.