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Article

MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).

Genes, chromosomes & cancer - 1 May 2005

Kozu Tomoko, Fukuyama Tomofusa, Yamami Tohru, Akagi Kiwamu, Kaneko Yasuhiko

Abstract excerpt

The AML1-MTG8 fusion gene is generated by chromosome translocation t(8;21), which is frequently observed in acute myeloid leukemia. The fusion gene produces a chimeric transcription factor that suppresses the expression of AML1-target genes via the MTG8 part of the chimeric protein, which is thought to be the primary cause of leukemia. The C-terminal region of MTG8 contains the MYND domain, represented by highly...

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Share to Alternative Splicing
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 8

Share to Core Binding Factor Alpha 2 Subunit

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Share to RUNX1 Translocation Partner 1 Protein

Share to Sequence Deletion

Share to Translocation, Genetic

Source

Identifiers

PMID: 15723339
DOI: 10.1002/gcc.20165

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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