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Article

Method for preservation of DNA stability of liquid-based cytology specimens from a lung adenocarcinoma cell line.

Virchows Archiv : an international journal of pathology - 1 Mar 2021

Matsuo Yukiko, Yamashita Kazuya, Yoshida Tsutomu, Satoh Yukitoshi

Abstract excerpt

Liquid-based cytology (LBC) specimens of lung adenocarcinoma have the potential to be widely used for genetic analysis. However, formaldehyde contained in some LBC preservation solutions can cause DNA fragmentation during specimen storage, rendering the samples unsuitable for molecular analysis. To investigate a novel preservation technique for improved DNA stability, which was evaluated by mutation analysis of...

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PMID: 32869115
DOI: 10.1007/s00428-020-02919-0

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