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Article

Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis

14 Jun 2019

Abstract excerpt

In addition to conventional cytology, liquid-based cytology (LBC) is also used for immunocytochemistry and gene analysis. However, an appropriate method to obtain high quality DNA for next-generation sequencing (NGS) using LBC specimens remains controversial. We determined the optimal conditions for fixation with an alcohol-based fixative for LBC and DNA extraction using cultured cancer cell lines and clinical...

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PMID: 31199826
DOI: 10.1371/journal.pone.0217724

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