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Evaluation of Cytologic Sample Preparations for Compatibility With Nucleic Acid Analysis

24 Jun 2021

Abstract excerpt

OBJECTIVES: In this study, the influence of several key elements of the cytologic sample workflow on DNA and RNA content was evaluated. METHODS: The A549 cell line, patient-derived organoids, and pleural effusions were used to investigate the effect of (1) several collection media and delayed time to processing; (2) cytology specimens; (3) cytologic staining; and (4) formalin-fixed, paraffin-embedded (FFPE) cell...

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PMID: 34542583
DOI: 10.1093/ajcp/aqab121

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