Article
Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Mar 2021
Sabbah Shereen, Liew Aaron, Brooks Augustin M, Kundu Rhiannon, Reading James L, Flatt Anneliese, Counter Claire, Choudhary Pratik, Forbes Shareen, Rosenthal Miranda J, Rutter Martin K, Cairns Stephanie, Johnson Paul, Casey John, Peakman Mark, Shaw James A, Tree Timothy I M
Abstract excerpt
Islet transplantation is an effective therapy for life-threatening hypoglycemia, but graft function gradually declines over time in many recipients. We characterized islet-specific T cells in recipients within an islet transplant program favoring alemtuzumab (ATZ) lymphodepleting induction and examined associations with graft function. Fifty-eight recipients were studied: 23 pretransplant and 40 posttransplant...
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