Article
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting.
Molecular cell - 3 Sept 2020
Robson Fran, Khan Khadija Shahed, Le Thi Khanh, Paris Clément, Demirbag Sinem, Barfuss Peter, Rocchi Palma, Ng Wai-Lung
Abstract excerpt
The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nucleoside analogs (NAs), exert their effect by incorporation into viral genomes and subsequent disruption of viral replication and fidelity. The development of anti-CoV...
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