Genetic and Phenotypic Basis of Autosomal Dominant Parkinson's Disease in a Large Multi-Center Cohort

Abstract excerpt

LRRK2, SNCA and VPS35 are unequivocally associated with autosomal dominant Parkinson’s disease (PD). We evaluated the prevalence of LRRK2, SNCA and VPS35 mutations and associated clinical features in a large French multi-center cohort of PD patients. Demographic and clinical data were collected for 1805 index cases (592 with autosomal dominant inheritance and 1213 isolated cases) since 1990. All probands were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurological disorders and treatments
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments