Article
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families.
Familial cancer - 1 Jan 2018
Dominguez-Valentin Mev, Nakken Sigve, Tubeuf Hélène, Vodak Daniel, Ekstrøm Per Olaf, Nissen Anke M, Morak Monika, Holinski-Feder Elke, Martins Alexandra, Møller Pål, Hovig Eivind
Abstract excerpt
To study the potential contribution of genes other than BRCA1/2, PTEN, and TP53 to the biological and clinical characteristics of multiple early-onset cancers in Norwegian families, including early-onset breast cancer, Cowden-like and Li-Fraumeni-like syndromes (BC, CSL and LFL, respectively). The Hereditary Cancer Biobank from the Norwegian Radium Hospital was used to identify early-onset BC, CSL or LFL for whom...
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