Article
Shrimp SIRT1 activates of the WSSV IE1 promoter independently of the NF-κB binding site.
Fish & shellfish immunology - 1 Nov 2020
Kao Zi-Ning, Liu Chun-Hung, Liu Wang-Jing, Kumar Ramya, Leu Jiann-Horng, Wang Han-Ching
Abstract excerpt
Since the mechanisms by which cellular factors modulate replication of the shrimp viral pathogen white spot syndrome virus (WSSV) are still largely unknown, here we consider the sirtuins, a family of NAD+-dependent protein deacetylases that are known to function as regulatory factors that activate or suppress viral transcription and replication in mammals. In particular, we focus on SIRT1 by isolating and...
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