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Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti–Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

25 Aug 2020

Abstract excerpt

Invasive Staphylococcus aureus infection is a leading cause of infectious disease–related deaths because S. aureus survives within host phagocytic cells, from which the bacteria are not adequately eliminated using current antibiotic treatments. Anti–S. aureus THIOMAB antibody-antibiotic conjugate (TAC), an anti–S. aureus antibody conjugated with antibiotic payload dmDNA31, was designed to deliver antibiotics into...

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PMID: 32839277
DOI: 10.1124/dmd.120.000092

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