Article
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease.
Human molecular genetics - 25 Nov 2020
Thom Christopher S, Ding Zhuoran, Levin Michael G, Damrauer Scott M, Lee Kyung Min, Lynch Julie, Chang Kyong-Mi, Tsao Philip S, Cho Kelly, Wilson Peter W F, Assimes Themistocles L, Sun Yan V, O'Donnell Christopher J, Vujkovic Marijana, Voight Benjamin F
Abstract excerpt
Clinical observations have linked tobacco smoking with increased type 2 diabetes risk. Mendelian randomization analysis has recently suggested smoking may be a causal risk factor for type 2 diabetes. However, this association could be mediated by additional risk factors correlated with smoking behavior, which have not been investigated. We hypothesized that body mass index (BMI) could help to explain the...
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