Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy.

Circulation journal : official journal of the Japanese Circulation Society - 25 Sept 2020

Nakashima Yasuteru, Kubo Toru, Sugiura Kenta, Ochi Yuri, Takahashi Asa, Baba Yuichi, Hirota Takayoshi, Yamasaki Naohito, Kimura Akinori, Doi Yoshinori L, Kitaoka Hiroaki

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is mainly caused by mutations in sarcomere genes. Regarding the clinical implications of genetic information, little is known about the lifelong clinical effect of sarcomere mutations in Japanese HCM patients. METHODS AND RESULTS: We studied 211 consecutive Japanese patients with HCM who had agreed to genetic testing between 2003 and 2013. Genetic analyses were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cardiac Myosins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic

Share to Myosin Heavy Chains

Share to Sarcomeres

Share to Tropomyosin

Share to Troponin I

Share to Troponin T

Source

Identifiers

PMID: 32830170
DOI: 10.1253/circj.CJ-20-0027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy.PMID 32830170Read ↗

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.Semantic proximity Read ↗

Penetrance of Hypertrophic Cardiomyopathy in Sarcomere Protein Mutation Carriers.Semantic proximity Read ↗

Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations.Semantic proximity Read ↗

Prevalence and Distribution of Sarcomeric Gene Mutations in Japanese Patients With Familial Hypertrophic CardiomyopathySemantic proximity Read ↗

Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction.Semantic proximity Read ↗

Significance of sarcomere gene mutations analysis in the end-stage phase of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Malignant effects of multiple rare variants in sarcomere genes on the prognosis of patients with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Characteristics and outcomes associated with sarcomere mutations in patients with hypertrophic cardiomyopathy: A systematic review and meta-analysis.Semantic proximity Read ↗

Value of Genetic Testing for the Prediction of Long-Term Outcome in Patients With Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Differential contributions of sarcomere and mitochondria-related multigene variants to the endophenotype of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Association of Multiple Nonhypertrophic Cardiomyopathy-Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.