Article
Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction.
Pediatric research - 1 Nov 2018
Takasaki Asami, Hirono Keiichi, Hata Yukiko, Wang Ce, Takeda Masafumi, Yamashita Jun K, Chang Bo, Nakaoka Hideyuki, Okabe Mako, Miyao Nariaki, Saito Kazuyoshi, Ibuki Keijiro, Ozawa Sayaka, Sekine Michikazu, Yoshimura Naoki, Nishida Naoki, Bowles Neil E, Ichida Fukiko
Abstract excerpt
BACKGROUND: Left ventricular noncompaction (LVNC) is a primary cardiomyopathy with heterogeneous genetic origins. The aim of this study was to elucidate the role of sarcomere gene variants in the pathogenesis and prognosis of LVNC. METHODS AND RESULTS: We screened 82 Japanese patients (0-35 years old), with a diagnosis of LVNC, for mutations in seven genes encoding sarcomere proteins, by direct DNA sequencing. We...
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