Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.

doi:10.1016/j.fsigen.2021.102478

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Article

Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy.

Forensic science international. Genetics - 1 May 2021

Mori Augusto Akira, Castro Lara Reinel de, Bortolin Raul Hernandes, Bastos Gisele Medeiros, Oliveira Victor Fernandes de, Ferreira Glaucio Monteiro, Hirata Thiago Dominguez Crespo, Fajardo Cristina Moreno, Sampaio Marcelo Ferraz, Moreira Dalmo Antonio Ribeiro, Pachón-Mateos José Carlos, Correia Edileide de Barros, Sousa Amanda Guerra de Moraes Rego, Brión Maria, Carracedo Angel, Hirata Rosario Dominguez Crespo, Hirata Mario Hiroyuki

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy (LVH) and is one of the major causes of sudden cardiac death (SCD). An exon-targeted gene sequencing strategy was used to investigate the association of functional variants in sarcomeric genes (MYBPC3, MYH7 and TNNT2) with severe LVH and other SCD-related risk factors in Brazilian HCM patients. Clinical data of 55 HCM...

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PMID: 33588347
DOI: 10.1016/j.fsigen.2021.102478

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