Article
Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action.
Mutation research - 1 Jan 2000
Ayrton A D, Ioannides C, Walker R
Abstract excerpt
The ability of anthraflavic acid to inhibit the mutagenicity of IQ was investigated using the Ames test and employing hepatic activation systems from Aroclor 1254-pretreated rats. Incorporation of anthraflavic acid into the S9 mix caused a concentration-dependent decrease in the mutagenicity of I...
Topics
- Animals
- Anthraquinones
- Biotransformation
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme Inhibitors
- Cytochromes
- Cytosol
- Isoenzymes
- Microsomes, Liver
- Mutation
- Quinolines
- Rats
- Salmonella typhimurium