Article
Choledochal Cysts Resected during Childhood Show No Mutations of KRAS and BRAF as Early Markers of Malignancy in Cholangiocytes.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie - 1 Feb 2021
Uecker Marie, Lehmann Ulrich, Braubach Peter, Schukfeh Nagoud, Madadi-Sanjani Omid, Ure Benno M, Petersen Claus, Kuebler Joachim F
Abstract excerpt
INTRODUCTION: In patients with choledochal cysts (CDC), a hyperplasia-dysplasia-carcinoma sequence can lead to biliary tract malignancy. The limited data available suggest that the risk decreases considerably after excision in childhood. We analyzed samples of resected CDC from pediatric patients histologically and performed mutational analysis of the proto-oncogenes KRAS and BRAF as early markers of malignant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.