De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.

doi:10.1016/j.jpedsurg.2020.03.008

Article

De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.

Journal of pediatric surgery - 1 Dec 2020

Schwab Marisa E, Song Hanbing, Mattis Aras, Phelps Andrew, Vu Lan T, Huang Franklin W, Nijagal Amar

Abstract excerpt

BACKGROUND/PURPOSE: Choledochal cysts are congenital dilations of the bile ducts, and are associated with an increased risk of malignant transformation. The purpose of this study is to report the outcomes of a large series of patients with choledochal cysts and to highlight our analysis of one patient who developed malignancy after cyst resection. METHODS: We conducted a retrospective review of patients <18 years...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.

Abstract excerpt

Topics

Related research