Article
NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2020
Vukojevic Vanja, Coynel David, Ghaffari Navid R, Freytag Virginie, Elbert Thomas, Kolassa Iris-Tatjana, Wilker Sarah, McGaugh James L, Papassotiropoulos Andreas, de Quervain Dominique J-F
Abstract excerpt
Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (n...
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