Article
PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012
de Quervain Dominique J-F, Kolassa Iris-Tatjana, Ackermann Sandra, Aerni Amanda, Boesiger Peter, Demougin Philippe, Elbert Thomas, Ertl Verena, Gschwind Leo, Hadziselimovic Nils, Hanser Edveena, Heck Angela, Hieber Petra, Huynh Kim-Dung, Klarhöfer Markus, Luechinger Roger, Rasch Björn, Scheffler Klaus, Spalek Klara, Stippich Christoph, Vogler Christian, Vukojevic Vanja, Stetak Attila, Papassotiropoulos Andreas
Abstract excerpt
Strong memory of a traumatic event is thought to contribute to the development and symptoms of posttraumatic stress disorder (PTSD). Therefore, a genetic predisposition to build strong memories could lead to increased risk for PTSD after a traumatic event. Here we show that genetic variability of the gene encoding PKCα (PRKCA) was associated with memory capacity--including aversive memory--in nontraumatized...
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