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Article

Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.

Nature neuroscience - 1 May 2011

Ghiasvand Noor M, Rudolph Dellaney D, Mashayekhi Mohammad, Brzezinski Joseph A, Goldman Daniel, Glaser Tom

Abstract excerpt

Individuals with nonsyndromic congenital retinal nonattachment (NCRNA) are totally blind from birth. The disease afflicts ∼1% of Kurdish people living in a group of neighboring villages in North Khorasan, Iran. We found that NCRNA is caused by a 6,523-bp deletion that spans a remote cis regulatory element 20 kb upstream from ATOH7 (Math5), a bHLH transcription factor gene that is required for retinal ganglion...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21441919
DOI: 10.1038/nn.2798
PMCID: PMC3083485

Genes

ATOH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.PMID 21441919Read ↗

The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell developmentSemantic proximity Read ↗

ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous.Semantic proximity Read ↗

Transcriptome analysis of the zebrafish <i>atoh7−/−</i> mutant, <i>lakritz</i> , highlights Atoh7-dependent genetic networks with potential implications for human eye diseasesSemantic proximity Read ↗

Atonal homolog 7 (ATOH7) loss-of-function mutations in predominant bilateral optic nerve hypoplasia.Semantic proximity Read ↗

Single cell transcriptomic analyses reveal the impact of bHLH factors ATOH7 and Neurog2 on human retinal organoid developmentSemantic proximity Read ↗

Next generation sequencing identifies mutations in Atonal homolog 7 (ATOH7) in families with global eye developmental defects.Semantic proximity Read ↗

Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid DevelopmentSemantic proximity Read ↗

Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.Semantic proximity Read ↗

Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinasSemantic proximity Read ↗

Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit.Semantic proximity Read ↗

OCULAR FEATURES ASSOCIATED WITH MUTATIONS IN ATOH7 GENE OVERLAP THOSE WITH FAMILIAL EXUDATIVE VITREORETINOPATHY.Semantic proximity Read ↗

Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.Semantic proximity Read ↗

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