Immunoglobulin kappa deleting element rearrangements are candidate targets for minimal residual disease evaluation in mantle cell lymphoma.

doi:10.1002/hon.2792

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Article

Immunoglobulin kappa deleting element rearrangements are candidate targets for minimal residual disease evaluation in mantle cell lymphoma.

Hematological oncology - 1 Dec 2020

Della Starza Irene, De Novi Lucia Anna, Cavalli Marzia, Novelli Noemi, Soscia Roberta, Genuardi Elisa, Mantoan Barbara, Drandi Daniela, Ferrante Martina, Monitillo Luigia, Barbero Daniela, Ciabatti Elena, Grassi Susanna, Bomben Riccardo, Degan Massimo, Gattei Valter, Galimberti Sara, Di Rocco Alice, Martelli Maurizio, Cortelazzo Sergio, Guarini Anna, Foà Robin, Ladetto Marco, Ferrero Simone, Del Giudice Ilaria

Abstract excerpt

Minimal residual disease (MRD) assessment is of high clinical relevance in patients with mantle cell lymphoma (MCL). In mature B-cell malignancies, the presence of somatic hypermutations (SHM) in Variable-Diversity-Joining Heavy chain (VDJH) rearrangements leads to frequent mismatches between primers, probes, and the target, thus impairing tumor cells quantification. Alternative targets, such as immunoglobulin...

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PMID: 32816326
DOI: 10.1002/hon.2792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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