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Article

Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB.

Nature microbiology - 1 Nov 2020

Hancock Steven J, Phan Minh-Duy, Luo Zhenyao, Lo Alvin W, Peters Kate M, Nhu Nguyen Thi Khanh, Forde Brian M, Whitfield Jason, Yang Ji, Strugnell Richard A, Paterson David L, Walsh Timothy R, Kobe Bostjan, Beatson Scott A, Schembri Mark A

Abstract excerpt

The IncC family of broad-host-range plasmids enables the spread of antibiotic resistance genes among human enteric pathogens1-3. Although aspects of IncC plasmid conjugation have been well studied4-9, many roles of conjugation genes have been assigned based solely on sequence similarity. We applied hypersaturated transposon mutagenesis and transposon-directed insertion-site sequencing to determine the set of...

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Identifiers

PMID: 32807890
DOI: 10.1038/s41564-020-0775-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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