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Article

Diltiazem on tacrolimus exposure and dose sparing in Chinese pediatric primary nephrotic syndrome: impact of CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms.

European journal of clinical pharmacology - 1 Jan 2021

Wang Junyan, Huang Lingfei, Gao Peng, Hu Yan, Ni Yinghua, Zhu Zhengyi, Zhang Liwen, Yang Jufei, Zhang Huifen, Fang Luo

Abstract excerpt

PURPOSE: To evaluate the role of diltiazem on tacrolimus sparing in pediatric primary nephrotic syndrome (PNS) and its relation to CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms. METHODS: The PNS children treated with tacrolimus and with steady-state trough concentration (C0) were retrospectively collected. The impacts of diltiazem on tacrolimus dose-adjusted C0 (C0/D), target concentration achievement, and...

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Identifiers

PMID: 32803289
DOI: 10.1007/s00228-020-02977-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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