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Article

Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase

10 Aug 2020

Abstract excerpt

genus, which comprises several important human pathogens. There is currently neither an approved vaccine nor antiviral drugs available to prevent infection by ZIKV. The nonstructural protein 5 (NS5) polymerase, which is responsible for replicating the viral RNA genome, represents one of the most promising targets for antiviral drug development. Starting from compounds recently developed against dengue virus NS5,...

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PMID: 32796069
DOI: 10.1128/jvi.00794-20

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