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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

27 Mar 2017

Abstract excerpt

The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the...

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PMID: 28345596
DOI: 10.1038/ncomms14764

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