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Novel guanosine derivatives against Zika virus polymerase in silico

22 Aug 2019

Abstract excerpt

The Zika virus (ZIKV) outbreak, which started in the year 2015, is considered the fastest and most widely spread outbreak reported for this flavivirus. The polymerase domain of the NS5 protein has been targeted in other viral infections and is recognized as a suitable target in ZIKV infection. Different novel modified compounds against ZIKV NS5 have been tested in silico. A few structures have been solved for...

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PMID: 31436327
DOI: 10.1002/jmv.25573

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