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Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures

13 Apr 2018

Abstract excerpt

A new Zika virus (ZIKV) outbreak started in 2015. According to the World Health Organization, 84 countries confirmed ZIKV infection. RNA-dependent RNA polymerase (RdRp) was an appealing target for drug designers during the last two decades. Through molecular docking, we screened 16 nucleotide/side inhibitors against ZIKV RdRp. While the mode of interaction with ZIKV is different from that in the hepatitis C virus...

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PMID: 29652194
DOI: 10.1080/1062936x.2018.1454981

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