A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk.

doi:10.1186/s13046-020-01652-5

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Article

A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk.

Journal of experimental & clinical cancer research : CR - 14 Aug 2020

Feng Tienan, Feng Nannan, Zhu Tengteng, Li Qiang, Zhang Qi, Wang Yu, Gao Ming, Zhou Baosen, Yu Herbert, Zheng Min, Qian Biyun

Abstract excerpt

BACKGROUND: Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood. METHODS: Association of SNP (rs140618127) in lncRNA LOC146880 with non-small cell lung cancer (NSCLC) was evaluated in a case-control study of 2707 individuals. The mechanism of the SNP's...

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PMID: 32795333
DOI: 10.1186/s13046-020-01652-5
PMCID: PMC7427888

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