Article
Costello syndrome model mice with a HrasG12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.
Cell death & disease - 13 Aug 2020
Katata Yu, Inoue Shin-Ichi, Asao Atsuko, Kobayashi Shuhei, Terui Hitoshi, Inoue-Shibui Aya, Abe Taiki, Niihori Tetsuya, Aiba Setsuya, Ishii Naoto, Kure Shigeo, Aoki Yoko
Abstract excerpt
Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the mechanisms underlying the dermatological abnormalities remain unclear. Here, we demonstrated that...
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