Article
Association of circadian clock TIMELESS variants and expression with asthma risk in children.
The clinical respiratory journal - 1 Dec 2020
Langwinski Wojciech, Sobkowiak Paulina, Narozna Beata, Wojsyk-Banaszak Irena, Dmitrzak-Węglarz Monika, Stachowiak Zuzanna, Nowakowska Joanna, Bręborowicz Anna, Szczepankiewicz Aleksandra
Abstract excerpt
INTRODUCTION: Bronchial asthma is a chronic respiratory disease characterized by airway inflammation, allergen-induced hypersensitivity and dyspnea. Most asthmatic patients demonstrate oscillations of disease symptoms within 24 hours regulated by circadian clock genes. We hypothesized that these genes may be regulators of childhood asthma risk. OBJECTIVES: The aim was to investigate whether single-nucleotide...
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