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Article

FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization.

The Journal of biological chemistry - 5 Feb 2010

Park Ok-Jin, Kim Hyun-Jung, Woo Kyung-Mi, Baek Jeong-Hwa, Ryoo Hyun-Mo

Abstract excerpt

Runx2 is a key transcription factor regulating osteoblast differentiation and skeletal morphogenesis, and FGF2 is one of the most important regulators of skeletal development. The importance of the ERK mitogen-activated protein (MAP) kinase pathway in cranial suture development was demonstrated by the findings that the inhibition of FGF/FGF receptor (FGFR) signaling by a MEK blocker prevents the premature suture...

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Source

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Identifiers

PMID: 20007706
DOI: 10.1074/jbc.M109.055053
PMCID: PMC2823497

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization.PMID 20007706Read ↗

RUNX2-modifying enzymes: therapeutic targets for bone diseasesSemantic proximity Read ↗

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FGFR2c-mediated ERK-MAPK activity regulates coronal suture development.Semantic proximity Read ↗

RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis.Semantic proximity Read ↗

Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.Semantic proximity Read ↗

Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulationSemantic proximity Read ↗

Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R miceSemantic proximity Read ↗

MAP Kinase-Dependent RUNX2 Phosphorylation Is Necessary for Epigenetic Modification of Chromatin During Osteoblast Differentiation.Semantic proximity Read ↗

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A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.Semantic proximity Read ↗

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