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Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway

17 Aug 2020

Abstract excerpt

High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate the ATR DNA damage repair pathway, and this is required for HPV genome amplification. In the present study, we show that HPV-induced ATR activation also leads to suppression of expression of inflammatory response genes. This suppression results from HPV-induced...

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PMID: 32788179
DOI: 10.1128/mbio.01628-20

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