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Human papillomaviruses target the double-stranded RNA protein kinase pathway

9 Oct 2006

Abstract excerpt

The double-stranded RNA protein kinase (PKR) pathway plays a vital role in the innate immune response to viral infection. Activation of PKR following virus entry can lead to a shutdown in translation, thereby inhibiting viral protein synthesis and replication. Little is currently known about whether human papillomaviruses (HPVs) modulate PKR expression and activity. In this study, normal human foreskin...

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PMID: 17030851
DOI: 10.1099/vir.0.82098-0

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