Article
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes.
Biological psychiatry - 1 Dec 2020
Popovic David, Ruef Anne, Dwyer Dominic B, Antonucci Linda A, Eder Julia, Sanfelici Rachele, Kambeitz-Ilankovic Lana, Oztuerk Omer Faruk, Dong Mark S, Paul Riya, Paolini Marco, Hedderich Dennis, Haidl Theresa, Kambeitz Joseph, Ruhrmann Stephan, Chisholm Katharine, Schultze-Lutter Frauke, Falkai Peter, Pergola Giulio, Blasi Giuseppe, Bertolino Alessandro, Lencer Rebekka, Dannlowski Udo, Upthegrove Rachel, Salokangas Raimo K R, Pantelis Christos, Meisenzahl Eva, Wood Stephen J, Brambilla Paolo, Borgwardt Stefan, Koutsouleris Nikolaos
Abstract excerpt
BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and heterogeneous effects on brain morphology might demand advanced mathematical modeling. Therefore, we present an unsupervised machine learning approach to characterize the clinical and neuroanatomical complexity of CT in a larger, transdiagnostic context. METHODS: We used a multicenter...
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