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Article

Childhood trauma moderates morphometric associations between orbitofrontal cortex and amygdala: implications for pathological personality traits.

Psychological medicine - 1 Oct 2022

Bounoua Nadia, Miglin Rickie, Spielberg Jeffrey M, Johnson Curtis L, Sadeh Naomi

Abstract excerpt

BACKGROUND: Research has demonstrated that chronic stress exposure early in development can lead to detrimental alterations in the orbitofrontal cortex (OFC)-amygdala circuit. However, the majority of this research uses functional neuroimaging methods, and thus the extent to which childhood trauma corresponds to morphometric alterations in this limbic-cortical network has not yet been investigated. This study had...

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Source

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Identifiers

PMID: 33261695
DOI: 10.1017/S0033291720004468
PMCID: PMC8319917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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