Article
Age-Related Co-Expression of BCOR and BCORL1 mRNA in Acute Myeloid Leukemia.
Clinical laboratory - 1 Aug 2020
Coskun Fatma R, Percin-Pacal Ferda, Emrence Zeliha, Ar Muhlis C, Abaci Neslihan, Unuvar Aysegul, Eskazan Ahmet E, Elverdi Tugrul, Salihoglu Ayse, Seflekci Yusuf, Karakas Zeynep, Soysal Teoman, Sirma-Ekmekci Sema
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematological malignancy caused by a variety of genetic abnormalities and epigenetic dysregulation. The incidence of AML is strongly related to age, with the highest incidence rates being in older adults. The loss of function mutations in BCOR and BCORL1 genes have been identified in AML. BCL6 corepressor (BCOR) and BCL6 corepressor like 1 (BCORL1) are...
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