Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort.

doi:10.1136/jnnp-2020-323279

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2020

Convery Rhian S, Bocchetta Martina, Greaves Caroline V, Moore Katrina M, Cash David M, Van Swieten John, Moreno Fermin, Sánchez-Valle Raquel, Borroni Barbara, Laforce Robert, Masellis Mario, Tartaglia Maria Carmela, Graff Caroline, Galimberti Daniela, Rowe James B, Finger Elizabeth, Synofzik Matthis, Vandenberghe Rik, de Mendonca Alexandre, Tagliavini Fabrizio, Santana Isabel, Ducharme Simon, Butler Christopher, Gerhard Alex, Levin Johannes, Danek Adrian, Otto Markus, Warren Jason D, Rohrer Jonathan D

Abstract excerpt

OBJECTIVE: Frontotemporal dementia (FTD) is typically associated with changes in behaviour, language and movement. However, recent studies have shown that patients can also develop an abnormal response to pain, either heightened or diminished. We aimed to investigate this symptom in mutation carriers within the Genetic FTD Initiative (GENFI). METHODS: Abnormal responsiveness to pain was measured in 462 GENFI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asymptomatic Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to C9orf72 Protein

Share to Corpus Striatum

Share to DNA Repeat Expansion

Share to Prefrontal Cortex

Share to Progranulins

Share to Temporal Lobe

Share to Thalamus

Source

Open in PubMed

Identifiers

PMID: 32759310
DOI: 10.1136/jnnp-2020-323279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort.PMID 32759310Read ↗

Genomic and transcriptomic profiles influence on brain morphology and their interactions with pain sensitivity individual differencesSemantic proximity Read ↗

Mutation Carriers with Reduced C-Afferent Density Reveal Cortical Dynamics of Pain-Action Relationship during Acute Pain.Semantic proximity Read ↗

Distinct Neuroanatomical Correlates of Neuropsychiatric Symptoms in the Three Main Forms of Genetic Frontotemporal Dementia in the GENFI Cohort.Semantic proximity Read ↗

Experimental Pain Phenotype Profiles in Community-dwelling Older Adults.Semantic proximity Read ↗

[Pain and cognitive impairment: from sensory indifference to neurodegenerative phenotype].Semantic proximity Read ↗

Could Altered Evoked Pain Responsiveness Be a Phenotypic Biomarker for Alzheimer's Disease Risk? A Cross-Sectional Analysis of Cognitively Healthy Individuals.Semantic proximity Read ↗

Clinical phenotype matters: structural and functional thalamic changes in neuropathic low-back pain.Semantic proximity Read ↗

Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain.Semantic proximity Read ↗

Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.Semantic proximity Read ↗

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and miceSemantic proximity Read ↗

Gray matter cortical thickness predicts individual pain sensitivity: a multi-center machine learning approachSemantic proximity Read ↗

Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.