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Article

Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism.

Translational psychiatry - 3 Aug 2020

Matoba Nana, Liang Dan, Sun Huaigu, Aygün Nil, McAfee Jessica C, Davis Jessica E, Raffield Laura M, Qian Huijun, Piven Joseph, Li Yun, Kosuri Sriam, Won Hyejung, Stein Jason L

Abstract excerpt

Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large genetically informative cohorts of individuals with ASD have led to the identification of a limited number of common genome-wide significant (GWS) risk loci to date. However, many more common genetic variants are expected to contribute to ASD risk given the high heritability. Here, we performed a genome-wide association study...

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PMID: 32747698
DOI: 10.1038/s41398-020-00953-9
PMCID: PMC7400671

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