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Article

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder.

PLoS genetics - 1 Feb 2021

Huang Kunling, Wu Yuchang, Shin Junha, Zheng Ye, Siahpirani Alireza Fotuhi, Lin Yupei, Ni Zheng, Chen Jiawen, You Jing, Keles Sunduz, Wang Daifeng, Roy Sushmita, Lu Qiongshi

Abstract excerpt

Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with rare variants, is incomplete. In this work, we introduce an analytical framework to quantify the transmission disequilibrium of genetically regulated gene expression...

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Identifiers

PMID: 33539344
DOI: 10.1371/journal.pgen.1009309
PMCID: PMC7888619

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