Article
Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with In Vivo Infection Assessment.
Infection and immunity - 18 Sept 2020
Wang Ying, Nair Arathy D S, Alhassan Andy, Jaworski Deborah C, Liu Huitao, Trinkl Kathleen, Hove Paidashe, Ganta Charan K, Burkhardt Nicole, Munderloh Ulrike G, Ganta Roman R
Abstract excerpt
Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic ehrlichiosis. In recent reports, we described substantial advances in developing random and targeted gene disruption methods to investigate the functions of E. chaffeensis genes. We reported earlier that the Himar1 transposon-based random mutagenesis is a valuable tool in defining E. chaffeensis genes...
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