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Article

A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis.

Scientific reports - 17 Nov 2017

Wang Ying, Wei Lanjing, Liu Huitao, Cheng Chuanmin, Ganta Roman R

Abstract excerpt

Obligate intracellular bacteria (obligates) belonging to Rickettsiales and Chlamydiales cause diseases in hundreds of millions of people worldwide and in many animal species. Lack of an efficient system for targeted mutagenesis in obligates remains a major impediment in understanding microbial pathogenesis. Challenges in creating targeted mutations may be attributed to essential nature of majority of the genes...

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Identifiers

PMID: 29150636
DOI: 10.1038/s41598-017-16023-y
PMCID: PMC5693922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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