Article
Targeted pharmacologic immunomodulation for inborn errors of immunity.
British journal of clinical pharmacology - 1 Jun 2022
Sacco Keith A, Stack Michael, Notarangelo Luigi D
Abstract excerpt
Inborn errors of immunity consist of over 400 known single gene disorders that may manifest with infection susceptibility, autoimmunity, autoinflammation, hypersensitivity and cancer predisposition. Most patients are treated symptomatically with immunoglobulin replacement, prophylactic antimicrobials or broad immunosuppression pertaining to their disease phenotype. Other than haematopoietic stem cell...
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