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Article

p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers.

Biochemical and biophysical research communications - 27 Aug 2020

Sano Hitoya, Futamura Manabu, Gaowa Siqin, Kamino Hiroki, Nakamura Yasuyuki, Yamaguchi Kazuya, Tanaka Yoshihiro, Yasufuku Itaru, Nakakami Akira, Arakawa Hirofumi, Yoshida Kazuhiro

Abstract excerpt

Mitochondria-eating protein (Mieap) plays a critical role in mitochondrial quality control (MQC) and functions as a p53-inducible tumor suppressor. This study aimed to examine its role in gastric cancer (GC) and esophageal cancer (EC). GC cells were infected with Mieap-overexpressing adenovirus (Ad-Mieap) and subjected to fluorescence-activated cell sorting (FACS), western blotting, and caspase assays....

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PMID: 32736677
DOI: 10.1016/j.bbrc.2020.05.168

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