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Article

Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects

30 Jul 2020

Abstract excerpt

Currently, no treatment exists to improve semen quality in most infertile men. Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Direct effects are plausible because KLOTHO is expressed in both germ cells and spermatozoa and forms with FGFR1 a specific receptor for the bone-derived...

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PMID: 32729975
DOI: 10.1096/fj.202000061rr

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