Article
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Nature - 1 Aug 2020
Aragona Mariaceleste, Sifrim Alejandro, Malfait Milan, Song Yura, Van Herck Jens, Dekoninck Sophie, Gargouri Souhir, Lapouge Gaëlle, Swedlund Benjamin, Dubois Christine, Baatsen Pieter, Vints Katlijn, Han Seungmin, Tissir Fadel, Voet Thierry, Simons Benjamin D, Blanpain Cédric
Abstract excerpt
The ability of the skin to grow in response to stretching has been exploited in reconstructive surgery1. Although the response of epidermal cells to stretching has been studied in vitro2,3, it remains unclear how mechanical forces affect their behaviour in vivo. Here we develop a mouse model in which the consequences of stretching on skin epidermis can be studied at single-cell resolution. Using a...
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