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Single cell transcriptomics of human epidermis identifies basal stem cell transition states

25 Aug 2020

Abstract excerpt

How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and bottom of rete ridges and transitional positions between the basal and suprabasal epidermal...

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PMID: 32843640
DOI: 10.1038/s41467-020-18075-7

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