Article
CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.
BMC genetics - 29 Jul 2020
Patel Manthan, Patel Divyesh, Datta Subhamoy, Singh Umashankar
Abstract excerpt
BACKGROUND: The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF. Interdependence between regulation of cytosine methylation and CTCF occupancy by CGGBP1 remains unknown. RESULTS: By analyzing methylated DNA-sequencing data obtained from CGGBP1-depleted cells, we report that some transcription factor-binding...
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