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Article

Multi-trait multi-locus SEM model discriminates SNPs of different effects.

BMC genomics - 28 Jul 2020

Igolkina Anna A, Meshcheryakov Georgy, Gretsova Maria V, Nuzhdin Sergey V, Samsonova Maria G

Abstract excerpt

BACKGROUND: There is a plethora of methods for genome-wide association studies. However, only a few of them may be classified as multi-trait and multi-locus, i.e. consider the influence of multiple genetic variants to several correlated phenotypes. RESULTS: We propose a multi-trait multi-locus model which employs structural equation modeling (SEM) to describe complex associations between SNPs and traits -...

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Identifiers

PMID: 32723302
DOI: 10.1186/s12864-020-06833-2
PMCID: PMC7385891

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